Breast Cancer Literature Review

Breast Cancer Literature Review-46
This paper presents findings on a number of breast density measurement and classification systems and associated technology, within population screening programs and the variations in estimations of the overall association between breast density and breast cancer risk.This report is a review of studies that focus on rural breast cancer survivorship.Studies of interest were randomized controlled trials (RCTs) or comparative non-randomized clinical trials (non-RCTs).

This paper presents findings on a number of breast density measurement and classification systems and associated technology, within population screening programs and the variations in estimations of the overall association between breast density and breast cancer risk.This report is a review of studies that focus on rural breast cancer survivorship.Studies of interest were randomized controlled trials (RCTs) or comparative non-randomized clinical trials (non-RCTs).

We extracted relevant information from 43 studies performed in Africa using the following criteria: case-control study, association between genetic variations and BC risk.

Data were provided on mutations and polymorphisms associated with BC without fixing a specific date.

Overall survival (n = 32) and progression-free survival (n = 30) were the most commonly reported efficacy outcomes. Targeted therapies, followed by chemotherapy in forms of combinations of 2 or more subclasses, composed most trials in TNBC, with immunotherapy being rarely used thus far.

The trials were mainly conducted in metastatic or advanced setting, followed by neoadjuvant and adjuvant settings.

Breast cancer (BC) is one of the most complex, diverse and leading cause of death in women worldwide.

The present investigation aims to explore genes panel associated with BC in different African regions, and compare them to those studied worldwide.

A search from January 2003 to July 2018 was performed on MEDLINE®, Embase, the Cochrane Central Database of Controlled Trials, and the US and European clinical trials registries.

Conference proceedings from ASCO, ESMO, and SABCS covering the period from 2016 to end of 2018 were also reviewed.

Therefore, it is necessary to encourage African researchers to characterize more genes involved in BC using methods generating global information such as next-generation sequencing in order to guide specific and more effective therapeutic strategies for the African community.

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